Fluorene

Fluorene

SCHEMBL17313625

O=S.c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.67
CES1 P23141 2/20 0.54
BCHE P06276 1/20 0.54
ALDH1A1 P00352 4/20 0.54
KDM4E B2RXH2 1/20 0.54
NPC1 O15118 1/20 0.54
LMNA P02545 1/20 0.54
MAPT P10636 1/20 0.54
HPGD P15428 1/20 0.54
RAB9A P51151 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
SRD5A2 P31213 1/20 0.52
CYP1A2 P05177 4/20 0.48
CYP3A4 P08684 1/20 0.48
TDP2 O95551 1/20 0.48
CASP3 P42574 1/20 0.48
CASP7 P55210 1/20 0.48
CASP9 P55211 1/20 0.48
CASP6 P55212 1/20 0.48
CASP8 Q14790 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorene SCHEMBL29478468 0.91 MAOA (0.68) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL29355380 0.91 MAOA (0.68) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL545861 0.91 MAOA (0.68) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL31388525 0.91 MAOA (0.68) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL8180 0.91 MAOA (0.68) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL8483194 0.88 MAOA (0.65) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL8378972 0.88 MAOA (0.65) MAOACES1BCHEALDH1A1KDM4E
SCHEMBL6481957 0.88 MAOA (0.65) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL2432881 0.88 MAOA (0.65) MAOACES1BCHEALDH1A1KDM4E
Fluorene SCHEMBL1080516 0.88 MAOA (0.65) MAOACES1BCHEALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9397301-B2 Sulfone group-containing compound, an organic light emitting diode (OLED) device having the same, and a method of fabricating the OLED device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD (CN) 2016-07-19 US claimed
US-20150357584-A1 A Sulfone Group-Containing Compound, An Organic Light Emitting Diode (OLED) Device Using The Same, and A Method of Fabricating the OLED Device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD. (CN) 2015-12-10 US claimed
US-9397301-B2 Sulfone group-containing compound, an organic light emitting diode (OLED) device having the same, and a method of fabricating the OLED device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD (CN) 2016-07-19 US disclosed
US-9397301-B2 Sulfone group-containing compound, an organic light emitting diode (OLED) device having the same, and a method of fabricating the OLED device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD (CN) 2016-07-19 US disclosed
US-20150357584-A1 A Sulfone Group-Containing Compound, An Organic Light Emitting Diode (OLED) Device Using The Same, and A Method of Fabricating the OLED Device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD. (CN) 2015-12-10 US disclosed
US-20150357584-A1 A Sulfone Group-Containing Compound, An Organic Light Emitting Diode (OLED) Device Using The Same, and A Method of Fabricating the OLED Device SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD. (CN) 2015-12-10 US disclosed
CN-102775398-A Novel bipolar material and application thereof VALIANT FINE CHEMICALS CO LTD 2012-11-14 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150357584-A1 A Sulfone Group-Containing Compound, An Organic Light Emitting Diode (OLED) Device Using The Same, and A Method of Fabricating the OLED Device OCIAD1, SULT1A1, STARD10 MAOA 1855/4885CES1 1629/4885BCHE 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.