Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17315780 | 0.87 | GRIN2B (0.34) | LMNAL3MBTL1GRIN2BPTGS1PTGS2 | |
| SCHEMBL16665045 | 0.86 | MEN1 (0.32) | KMT2AHTTMEN1 | |
| SCHEMBL17315769 | 0.75 | GRIN2B (0.32) | GRIN2BCA2 | |
| SCHEMBL17583189 | 0.75 | CA2 (0.40) | L3MBTL1HTTCA2 | |
| SCHEMBL17315775 | 0.73 | HTT (0.37) | LMNAL3MBTL1GRIN2BPTGS2KMT2A | |
| SCHEMBL17315776 | 0.73 | GRIN2B (0.34) | GRIN2BPTGS2CA2 | |
| SCHEMBL14921130 | 0.72 | LMNA (0.39) | LMNAL3MBTL1GRIN2BHTTTRPM8 | |
| SCHEMBL17325379 | 0.72 | GRIN2B (0.38) | LMNAL3MBTL1GRIN2BHTTCYP2C9 | |
| SCHEMBL14920915 | 0.72 | GRIN2B (0.40) | LMNAL3MBTL1GRIN2BHTTCYP2C9 | |
| SCHEMBL17583126 | 0.69 | CA2 (0.38) | L3MBTL1GRIN2BPTGS1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152213-B1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS CAYMAN LTD (KY) | 2018-10-31 | — | — | EP | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| EP-3152213-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | Rugen Holdings (Cayman) Limited (KY) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015187845-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2015-12-10 | — | — | WO | disclosed |
| WO-2015187845-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | GRIN1, GRIN2A, GRIN2B | LMNA 4634/4885L3MBTL1 3260/4885GRIN2B 3/4885 |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | GRIN1, GRIN2A, GRIN2B | LMNA 4634/4885L3MBTL1 3260/4885GRIN2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.