Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17315778 | 0.84 | GRIN2B (0.39) | GRIN2BHTTALDH1A1HSD17B10GAA | |
| SCHEMBL16552187 | 0.82 | PLAU (0.40) | PLAUHTTALDH1A1GAA | |
| SCHEMBL14921239 | 0.82 | ALDH1A1 (0.53) | L3MBTL1PLAUSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL15999652 | 0.82 | ALDH1A1 (0.33) | L3MBTL1PLAUHTTALDH1A1GAA | |
| SCHEMBL17325379 | 0.81 | GRIN2B (0.38) | LMNAL3MBTL1GRIN2BPLAUCYP2C9 | |
| SCHEMBL14920915 | 0.81 | GRIN2B (0.40) | LMNAL3MBTL1GRIN2BPLAUCYP2C9 | |
| SCHEMBL17964135 | 0.78 | HTT (0.43) | LMNAL3MBTL1GRIN2BPLAUCYP2C9 | |
| SCHEMBL20271591 | 0.77 | HTT (0.36) | LMNASMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL21994824 | 0.75 | CYP2C9 (0.37) | LMNAL3MBTL1GRIN2BPLAUCYP2C9 | |
| SCHEMBL14921080 | 0.73 | LMNA (0.41) | LMNAL3MBTL1PLAUCYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152213-B1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS CAYMAN LTD (KY) | 2018-10-31 | — | — | EP | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2018-07-24 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | RUGEN HOLDINGS (CAYMAN) LIMITED (KY) | 2017-04-13 | — | — | US | disclosed |
| EP-3152213-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | Rugen Holdings (Cayman) Limited (KY) | 2017-04-12 | — | — | EP | disclosed |
| US-9301526-B2 | Compounds with nematicidal activity | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-05 | — | — | US | disclosed |
| US-9301526-B2 | Compounds with nematicidal activity | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-05 | — | — | US | disclosed |
| US-20140249149-A1 | Compounds with Nematicidal Activity | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-04 | — | — | US | disclosed |
| CN-104023540-A | COMPOUNDS WITH NEMATICIDAL ACTIVITY | BAYER IP GMBH | 2014-09-03 | — | — | CN | disclosed |
| EP-2606727-A1 | Compounds with nematicidal activity | Bayer CropScience AG (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2606727-A1 | Compounds with nematicidal activity | Bayer CropScience AG (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2606728-A1 | Compounds with nematicidal activity | Bayer CropScience AG (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2606728-A1 | Compounds with nematicidal activity | Bayer CropScience AG (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2013064461-A2 | COMPOUNDS WITH NEMATICIDAL ACTIVITY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013064460-A1 | COMPOUNDS WITH NEMATICIDAL ACTIVITY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013064460-A1 | COMPOUNDS WITH NEMATICIDAL ACTIVITY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013064461-A2 | COMPOUNDS WITH NEMATICIDAL ACTIVITY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10030026-B2 | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists | GRIN1, GRIN2A, GRIN2B | LMNA 4634/4885L3MBTL1 3260/4885GRIN2B 3/4885 |
| US-20140249149-A1 | Compounds with Nematicidal Activity | ACHE, NAAA, TUBA3C | LMNA 1201/4885L3MBTL1 1501/4885GRIN2B 2183/4885 |
| US-20170101412-A1 | DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS | GRIN1, GRIN2A, GRIN2B | LMNA 4634/4885L3MBTL1 3260/4885GRIN2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.