Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16137463 | 0.83 | TDP1 (0.30) | — | |
| SCHEMBL3296973 | 0.74 | RXRA (0.40) | RXRARXRB | |
| SCHEMBL26664801 | 0.73 | TRPA1 (0.32) | — | |
| SCHEMBL8579862 | 0.72 | RXRA (0.41) | RXRARXRB | |
| SCHEMBL3295540 | 0.69 | HDAC8 (0.41) | RXRARXRB | |
| SCHEMBL15643948 | 0.66 | PTGS2 (0.30) | — | |
| SCHEMBL3812836 | 0.66 | — | — | |
| SCHEMBL3397518 | 0.66 | — | — | |
| SCHEMBL702655 | 0.65 | PRSS1 (0.33) | — | |
| SCHEMBL9078640 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148539-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3148539-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015187542-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC. (US) | 2015-12-10 | — | — | WO | disclosed |