SCHEMBL17316352

SCHEMBL17316352

COS(=O)(=O)c1ccc(C)cc1C1COC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCOLN3 Q8TDD5 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
USP2 O75604 2/20 0.34
GAA P10253 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
ALDH1A1 P00352 3/20 0.33
TSHR P16473 4/20 0.33
MAPK1 P28482 2/20 0.33
TP53 P04637 1/20 0.33
CASP1 P29466 1/20 0.33
LMNA P02545 2/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNA4 P43681 1/20 0.32
MAPT P10636 2/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
KDM4E B2RXH2 1/20 0.31
F2 P00734 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17476551 0.89 ALDH1A1 (0.36) MCOLN3L3MBTL1USP2GAAKMT2A
SCHEMBL14157165 0.86 SMN1; SMN2 (0.34) MCOLN3L3MBTL1SMN1; SMN2ALDH1A1TSHR
SCHEMBL2565711 0.86 L3MBTL1 (0.32) MCOLN3L3MBTL1USP2GAAKMT2A
SCHEMBL8445070 0.86 L3MBTL1 (0.40) MCOLN3L3MBTL1USP2GAAKMT2A
SCHEMBL29504740 0.85 ALDH1A1 (0.40) MCOLN3L3MBTL1SMN1; SMN2ALDH1A1TSHR
SCHEMBL16166457 0.85 ALDH1A1 (0.40) MCOLN3L3MBTL1SMN1; SMN2ALDH1A1TSHR
SCHEMBL28467370 0.84 TSHR (0.34) MCOLN3L3MBTL1KMT2AALDH1A1TSHR
SCHEMBL6086222 0.83 PTGDR2 (0.42) MCOLN3L3MBTL1USP2GAAKMT2A
SCHEMBL2951235 0.82 LMNA (0.32) MCOLN3KMT2AALDH1A1TSHRLMNA
SCHEMBL17294413 0.82 TSHR (0.32) MCOLN3L3MBTL1USP2GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3152199-A1 PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS Actelion Pharmaceuticals Ltd. (CH) 2017-04-12 EP disclosed
WO-2015186056-A1 PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS ACTELION PHARMACEUTICALS LTD (CH) 2015-12-10 WO disclosed