Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9608890 | 0.83 | GAA (0.44) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL23571796 | 0.79 | ADORA2B (0.44) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL14621515 | 0.79 | KCNJ6 (0.40) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL22149944 | 0.77 | KDM4E (0.42) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL8297013 | 0.76 | GAA (0.47) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL4359364 | 0.72 | PTGS2 (0.47) | ALDH1A1KDM4ELMNAGAAPOLB | |
| SCHEMBL12875692 | 0.72 | LMNA (0.39) | ALDH1A1KDM4EGLAGLSLMNA | |
| SCHEMBL256691 | 0.71 | — | — | |
| SCHEMBL23467588 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAGAAPOLB | |
| SCHEMBL21768349 | 0.68 | GAA (0.43) | ALDH1A1KDM4EGLAGLSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353544-A1 | NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353544-A1 | NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | ALDH1A1 2883/4885KDM4E 1692/4885GLA 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.