Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12157407 | 0.83 | ENPP2 (0.43) | ENPP2PTGS2SMN1; SMN2PTGS1DAO | |
| SCHEMBL942878 | 0.77 | ENPP2 (0.54) | ENPP2PTGS2DAO | |
| SCHEMBL2376239 | 0.75 | ENPP2 (0.72) | ENPP2PTGS2 | |
| SCHEMBL2991047 | 0.75 | PTGS2 (0.67) | ENPP2PTGS2SMN1; SMN2PTGS1AKR1C3 | |
| SCHEMBL12157583 | 0.74 | ENPP2 (0.38) | ENPP2PTGS2SMN1; SMN2PTGS1 | |
| SCHEMBL14798087 | 0.72 | BCL2L1 (0.35) | — | |
| SCHEMBL2303866 | 0.72 | — | — | |
| SCHEMBL11986371 | 0.70 | PKM (0.70) | PTGS2PTGS1AKR1C3 | |
| SCHEMBL280156 | 0.70 | PKM (0.70) | PTGS2PTGS1AKR1C3 | |
| SCHEMBL9292515 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187089-A1 | MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2015-12-10 | — | — | WO | disclosed |