Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326569 | 0.88 | RXRA (0.50) | RXRASMN1; SMN2HSD17B10THRBPTGER1 | |
| SCHEMBL17326619 | 0.86 | RXRA (0.47) | RXRASMN1; SMN2HSD17B10THRBTYMS | |
| SCHEMBL17326599 | 0.86 | RXRA (0.52) | RXRASMN1; SMN2HSD17B10THRB | |
| SCHEMBL17326617 | 0.79 | RXRA (0.48) | RXRATYMSPTGER1MRGPRX4KDM4E | |
| SCHEMBL18950565 | 0.75 | HSD17B10 (0.70) | RXRASMN1; SMN2HSD17B10THRBKDM4E | |
| SCHEMBL17326555 | 0.74 | RXRA (0.47) | RXRASMN1; SMN2HSD17B10THRBPTGER1 | |
| SCHEMBL17326600 | 0.73 | RXRA (0.61) | RXRASMN1; SMN2THRB | |
| SCHEMBL3918347 | 0.71 | GLRA1 (0.59) | RXRASMN1; SMN2THRBPTGER1MRGPRX4 | |
| SCHEMBL2030743 | 0.67 | SIRT2 (0.71) | HSD17B10KDM4E | |
| SCHEMBL2696717 | 0.67 | HSD17B10 (0.58) | SMN1; SMN2HSD17B10THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |