Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326599 | 0.89 | RXRA (0.52) | RXRARXRBRXRGSMN1; SMN2THRB | |
| SCHEMBL17326618 | 0.88 | RXRA (0.50) | RXRASMN1; SMN2THRBHSD17B10HTT | |
| SCHEMBL17326555 | 0.86 | RXRA (0.47) | RXRARXRBRXRGPPARGSMN1; SMN2 | |
| SCHEMBL17326622 | 0.78 | RXRA (0.51) | RXRARXRBRXRGPPARGHCAR3 | |
| SCHEMBL25484510 | 0.77 | RXRA (0.68) | RXRARXRBRXRGPPARGEP300 | |
| SCHEMBL17326600 | 0.75 | RXRA (0.61) | RXRAPPARGSMN1; SMN2THRBHCAR3 | |
| SCHEMBL17326619 | 0.74 | RXRA (0.47) | RXRARXRBRXRGPPARGSMN1; SMN2 | |
| SCHEMBL29462123 | 0.73 | HCAR3 (0.50) | RXRARXRBRXRGPPARGHCAR3 | |
| SCHEMBL29462128 | 0.73 | HCAR3 (0.50) | RXRARXRBRXRGPPARGHCAR3 | |
| SCHEMBL26114008 | 0.73 | HCAR3 (0.50) | RXRARXRBRXRGPPARGHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |