Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326555 | 0.88 | RXRA (0.47) | RXRAPPARGNR1H3PTGER1SMN1; SMN2 | |
| SCHEMBL17326600 | 0.87 | RXRA (0.61) | RXRAPPARGNR1H3SMN1; SMN2THRB | |
| SCHEMBL17326618 | 0.86 | RXRA (0.50) | RXRAPTGER1SMN1; SMN2HSD17B10MRGPRX4 | |
| SCHEMBL17326617 | 0.77 | RXRA (0.48) | RXRAPTGER1MRGPRX4TYMSRXRB | |
| SCHEMBL17326569 | 0.74 | RXRA (0.50) | RXRAPPARGPTGER1SMN1; SMN2HSD17B10 | |
| SCHEMBL17326599 | 0.73 | RXRA (0.52) | RXRASMN1; SMN2HSD17B10THRBRXRB | |
| SCHEMBL21577138 | 0.71 | RXRA (0.45) | RXRAPPARGNR1H3HSD17B10MRGPRX4 | |
| SCHEMBL22235452 | 0.69 | RXRA (0.54) | RXRAPPARGNR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL3918347 | 0.69 | GLRA1 (0.59) | RXRAPTGER1SMN1; SMN2MRGPRX4THRB | |
| SCHEMBL1354911 | 0.69 | PTGER1 (0.58) | PTGER1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |