Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17326792 | 0.92 | KDM4E (0.43) | KDM4EALDH1A1HPGDL3MBTL1PLA2G4A | |
| SCHEMBL17326620 | 0.87 | AR (0.38) | KDM4EALDH1A1HPGDROCK2PIM1 | |
| SCHEMBL17326801 | 0.84 | RXRA (0.41) | KDM4EALDH1A1HPGDL3MBTL1PLA2G4A | |
| SCHEMBL17326803 | 0.79 | AR (0.39) | KDM4EALDH1A1HPGDROCK2PIM1 | |
| SCHEMBL17326802 | 0.74 | RXRA (0.48) | PLA2G4A | |
| SCHEMBL17129126 | 0.72 | MAPT (0.50) | KDM4EALDH1A1HPGDL3MBTL1NPC1 | |
| SCHEMBL17326601 | 0.72 | RXRA (0.50) | ALDH1A1HPGDPLA2G4A | |
| SCHEMBL17326621 | 0.72 | RXRA (0.42) | KDM4EALDH1A1HPGDROCK2PIM1 | |
| SCHEMBL140918 | 0.72 | ROCK2 (0.47) | KDM4EALDH1A1HPGDROCK2PIM1 | |
| SCHEMBL149014 | 0.71 | KDM4E (0.54) | KDM4EALDH1A1HPGDL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015187850-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF OCULAR DISORDERS | DUKE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |