Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 8/20 | 0.30 |
| ▸ | DCK | P27707 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18479255 | 0.86 | LOX (0.38) | MAPTKDM4EAPP | |
| SCHEMBL31274754 | 0.79 | HPGD (0.39) | MAPTKDM4ES1PR1 | |
| SCHEMBL19346801 | 0.79 | HPGD (0.39) | MAPTKDM4ES1PR1 | |
| SCHEMBL22759822 | 0.75 | NQO2 (0.41) | MAPT | |
| SCHEMBL21078949 | 0.73 | MAPT (0.42) | MAPTPDE10APDE3BPDE3AKDM4E | |
| SCHEMBL23044965 | 0.73 | SCN5A (0.37) | S1PR1 | |
| SCHEMBL30932094 | 0.73 | SCN5A (0.37) | S1PR1 | |
| SCHEMBL16943097 | 0.71 | MAPT (0.37) | MAPTPDE10AS1PR1PIK3CAHDAC1 | |
| SCHEMBL31638058 | 0.71 | LOX (0.41) | KDM4EAPP | |
| SCHEMBL15969491 | 0.71 | MBOAT4 (0.35) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154970-B1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-3154970-B1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME (US) | 2019-11-06 | — | — | EP | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-9808542-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9808542-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9808542-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| EP-3154970-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | Merck Sharp & Dohme Corp. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015188368-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015191506-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015191506-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015188368-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MAPT, SNCA, PARK7 | MAPT 1/4885PDE10A 1095/4885PDE3B 565/4885 |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MAPT, SNCA, PARK7 | MAPT 1/4885PDE10A 1452/4885PDE3B 737/4885 |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MAPT, SNCA, PARK7 | MAPT 1/4885PDE10A 1095/4885PDE3B 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.