Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15419069 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2CYP2C19 | |
| SCHEMBL1733831 | 0.81 | PTGS1 (0.43) | ALDH1A1KDM4EMAPTSMN1; SMN2CYP2C19 | |
| SCHEMBL3764681 | 0.77 | KDM4E (0.59) | ALDH1A1KDM4EMAPTSMN1; SMN2CYP2C19 | |
| SCHEMBL1735826 | 0.77 | ADORA2A (0.59) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL217845 | 0.77 | ALDH1A3 (0.58) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL216669 | 0.74 | NR4A2 (0.49) | ALDH1A1KDM4ESMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL219498 | 0.74 | NPC1 (0.56) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2439713 | 0.74 | NR4A2 (0.58) | ALDH1A1CYP2C9EGLN1 | |
| SCHEMBL217206 | 0.73 | ALDH1A3 (0.54) | ALDH1A1KDM4ESMN1; SMN2NPC1CYP2C9 | |
| SCHEMBL219492 | 0.73 | NPC1 (0.57) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| EP-2225243-B1 | Derivatives of N-heterocyclic-6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-11-16 | — | — | EP | claimed |