Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338637 | 0.92 | POLB (0.51) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338541 | 0.90 | LMNA (0.57) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338532 | 0.90 | POLB (0.52) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338565 | 0.84 | MAPT (0.53) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338542 | 0.84 | GABRA1 (0.64) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338555 | 0.83 | POLB (0.49) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338533 | 0.82 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1HPGDGABRA1GABRB2 | |
| SCHEMBL17338634 | 0.81 | POLB (0.47) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338586 | 0.81 | ALDH1A1 (0.54) | POLBLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17338577 | 0.81 | POLB (0.48) | POLBLMNASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |