Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20059249 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL17339198 | 0.85 | LMNA (0.40) | ALDH1A1HPGDPOLBLMNAMAPT | |
| SCHEMBL13039964 | 0.73 | CYP2D6 (0.50) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL6871392 | 0.73 | CYP2D6 (0.50) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL6719047 | 0.72 | CYP2D6 (0.46) | TAAR1POLBCYP2D6LMNAKDM4E | |
| SCHEMBL17339199 | 0.72 | CYP2D6 (0.46) | TAAR1POLBCYP2D6LMNAKDM4E | |
| SCHEMBL6725960 | 0.69 | CYP2D6 (0.49) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL10169593 | 0.69 | CYP2D6 (0.46) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL14847482 | 0.69 | CYP2D6 (0.46) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL1044302 | 0.69 | CYP2D6 (0.49) | ALDH1A1TAAR1POLBCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536541-B | Process for the preparation of ramipril | 赛诺菲-安万特德国有限公司 | 2021-01-08 | — | — | CN | disclosed |
| US-10112973-B2 | Process for the preparation of ramipril | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2018-10-30 | — | — | US | disclosed |
| EP-3154940-B1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2018-04-18 | — | — | EP | disclosed |
| EP-3154940-B1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2018-04-18 | — | — | EP | disclosed |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2017-06-08 | — | — | US | disclosed |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2017-06-08 | — | — | US | disclosed |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2017-06-08 | — | — | US | disclosed |
| EP-3154940-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | Sanofi-Aventis Deutschland GmbH (DE) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015189108-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015189108-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10112973-B2 | Process for the preparation of ramipril | CYP2S1, CYP3A5, CYP4B1 | ALDH1A1 162/4885HPGD 365/4885TAAR1 1968/4885 |
| US-20170158733-A1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | CYP2S1, CYP3A5, CYP4B1 | ALDH1A1 162/4885HPGD 365/4885TAAR1 1968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.