Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17339207 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL17339198 | 0.85 | LMNA (0.40) | ALDH1A1HPGDPOLBLMNAMAPT | |
| SCHEMBL13039964 | 0.73 | CYP2D6 (0.50) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL6871392 | 0.73 | CYP2D6 (0.50) | ALDH1A1HPGDTAAR1POLBCYP2D6 | |
| SCHEMBL6719047 | 0.72 | CYP2D6 (0.46) | TAAR1POLBCYP2D6LMNAKDM4E | |
| SCHEMBL17339199 | 0.72 | CYP2D6 (0.46) | TAAR1POLBCYP2D6LMNAKDM4E | |
| SCHEMBL6725960 | 0.69 | CYP2D6 (0.49) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL10169593 | 0.69 | CYP2D6 (0.46) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL14847482 | 0.69 | CYP2D6 (0.46) | ALDH1A1TAAR1POLBCYP2D6LMNA | |
| SCHEMBL1044302 | 0.69 | CYP2D6 (0.49) | ALDH1A1TAAR1POLBCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154940-B1 | PROCESS FOR THE PREPARATION OF RAMIPRIL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2018-04-18 | — | — | EP | disclosed |