Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340063 | 0.93 | SLC6A2 (0.56) | SIGMAR1SLC6A2SLC6A4SLC6A3HTT | |
| SCHEMBL17753539 | 0.93 | SIGMAR1 (0.77) | SIGMAR1DRD2DRD4DRD3SLC6A2 | |
| SCHEMBL8273969 | 0.90 | SIGMAR1 (0.65) | SIGMAR1DRD2DRD4DRD3SLC6A2 | |
| SCHEMBL17340068 | 0.84 | DRD2 (0.56) | SIGMAR1DRD2DRD4DRD3HTT | |
| SCHEMBL17339768 | 0.84 | TP53 (0.54) | SIGMAR1HTTMEN1KMT2AHTR1A | |
| SCHEMBL8273974 | 0.82 | SLC6A2 (0.55) | SIGMAR1SLC6A2SLC6A4SLC6A3HTT | |
| SCHEMBL17340067 | 0.81 | KCNH2 (0.58) | SIGMAR1DRD2DRD4DRD3HTT | |
| SCHEMBL17340053 | 0.79 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD4DRD3HTT | |
| SCHEMBL17339771 | 0.79 | CCR3 (0.53) | SIGMAR1DRD2DRD4DRD3MEN1 | |
| SCHEMBL8099595 | 0.78 | SIGMAR1 (0.68) | SIGMAR1DRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |