Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753545 | 0.91 | GRIN1 (0.63) | CCR3GRIN1GRIN2ADRD2DRD4 | |
| SCHEMBL8273956 | 0.89 | TDP1 (0.54) | GRIN1GRIN2AKMT2AMEN1TDP1 | |
| SCHEMBL17340067 | 0.88 | KCNH2 (0.58) | CCR3KMT2AMEN1SMN1; SMN2DRD2 | |
| SCHEMBL17340068 | 0.84 | DRD2 (0.56) | CCR3KMT2AMEN1TDP1KDM4E | |
| SCHEMBL17340054 | 0.84 | TDP1 (0.53) | CCR3KMT2AMEN1TDP1KDM4E | |
| SCHEMBL17340053 | 0.83 | SIGMAR1 (0.64) | CCR3KMT2AMEN1TDP1KDM4E | |
| SCHEMBL17339769 | 0.81 | MEN1 (0.62) | KMT2AMEN1SMN1; SMN2TP53CHRM2 | |
| SCHEMBL17339767 | 0.79 | SIGMAR1 (0.67) | KMT2AMEN1DRD2DRD4DRD3 | |
| SCHEMBL9372179 | 0.77 | SIGMAR1 (0.72) | KMT2AMEN1TDP1SIGMAR1L3MBTL1 | |
| SCHEMBL13705517 | 0.77 | KCNH2 (0.57) | KMT2AMEN1TDP1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160136115-A1 | T TYPE CALCIUM CHANNEL INHIBITORS | UNIVERSITY OF VIRGINIA | 2016-05-19 | — | — | US | disclosed |
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160136115-A1 | T TYPE CALCIUM CHANNEL INHIBITORS | CACNA1H, CACNA1I, CACNA1G | CCR3 685/4885GRIN1 850/4885GRIN2A 1714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.