Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MITF | O75030 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753544 | 0.91 | CHRM2 (0.63) | MEN1KMT2ATP53CHRM2CNR1 | |
| SCHEMBL8273074 | 0.89 | MEN1 (0.61) | MEN1KMT2ATP53CHRM2GPR55 | |
| SCHEMBL17340053 | 0.88 | SIGMAR1 (0.64) | MEN1KMT2ATP53GPR55HTT | |
| SCHEMBL6327377 | 0.86 | MEN1 (0.73) | MEN1KMT2ATP53CHRM2GPR55 | |
| SCHEMBL17340068 | 0.84 | DRD2 (0.56) | MEN1KMT2ATP53GPR55HTT | |
| SCHEMBL17339768 | 0.83 | TP53 (0.54) | MEN1KMT2ATP53CHRM2GPR55 | |
| SCHEMBL17340067 | 0.83 | KCNH2 (0.58) | MEN1KMT2ATP53GPR55HTT | |
| SCHEMBL17339771 | 0.81 | CCR3 (0.53) | MEN1KMT2ATP53CHRM2SMN1; SMN2 | |
| SCHEMBL6322828 | 0.80 | MEN1 (0.86) | MEN1KMT2ATP53GPR55HTT | |
| SCHEMBL17340069 | 0.78 | SIGMAR1 (0.60) | MEN1KMT2ATP53GPR55HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160136115-A1 | T TYPE CALCIUM CHANNEL INHIBITORS | UNIVERSITY OF VIRGINIA | 2016-05-19 | — | — | US | disclosed |
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212127-B2 | T type calcium channel inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2015-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160136115-A1 | T TYPE CALCIUM CHANNEL INHIBITORS | CACNA1H, CACNA1I, CACNA1G | MEN1 429/4885KMT2A 3549/4885TP53 3976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.