Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CCR9 | P51686 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 5/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874498 | 0.82 | ALDH1A1 (0.58) | MAPTLMNAALDH1A1HTTCCR9 | |
| SCHEMBL29603162 | 0.79 | HPGD (0.56) | MAPTLMNAALDH1A1HTTCCR9 | |
| SCHEMBL9930686 | 0.78 | CCR2 (0.58) | CCR9HPGDALOX15TSHRMAPK1 | |
| SCHEMBL949422 | 0.76 | MAOB (0.55) | ALDH1A1CCR9HPGDALOX15TSHR | |
| SCHEMBL15045384 | 0.76 | KMT2A (0.60) | MAPTLMNAALDH1A1HPGDPTPN2 | |
| SCHEMBL1321693 | 0.76 | CYP3A4 (0.53) | MAPTLMNAALDH1A1HTTCCR9 | |
| SCHEMBL8429603 | 0.75 | MAOB (0.56) | LMNAALDH1A1CCR9HPGDALOX15 | |
| SCHEMBL3906753 | 0.74 | ALDH1A1 (0.47) | MAPTLMNAALDH1A1HTTCCR9 | |
| SCHEMBL22635624 | 0.73 | MAOB (0.74) | ALDH1A1HPGDALOX15TSHRMAPK1 | |
| SCHEMBL29652385 | 0.73 | KMT2A (0.57) | MAPTLMNAALDH1A1HTTCCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955173-A1 | NOVEL 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-12-16 | — | — | EP | disclosed |