Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 15/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.58 |
| ▸ | RELA | Q04206 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30331845 | 1.00 | FOLH1 (0.59) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL27668461 | 0.98 | FOLH1 (0.58) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL6000790 | 0.85 | MRGPRX4 (0.68) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL7053494 | 0.84 | MAOB (0.55) | MRGPRX4 | |
| SCHEMBL13316468 | 0.83 | FOLH1 (0.61) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL6761544 | 0.82 | MRGPRX4 (0.57) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL27668384 | 0.82 | FOLH1 (0.56) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL30628893 | 0.81 | MRGPRX4 (0.67) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL565902 | 0.81 | MRGPRX4 (0.67) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL28613106 | 0.81 | FOLH1 (0.59) | FOLH1MRGPRX4TP53NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190000832-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | Selder Pharma Inc. (US) | 2019-01-03 | — | — | US | disclosed |
| US-20150359787-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC. (US) | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150359787-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | FOLH1 2555/4885MRGPRX4 151/4885TP53 4846/4885 |
| US-20190000832-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | FOLH1 2555/4885MRGPRX4 151/4885TP53 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.