Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10243929 | 1.00 | PKLR (0.49) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL10244111 | 0.88 | ALDH1A1 (0.47) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL10244148 | 0.84 | RAB9A (0.48) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL17350939 | 0.84 | RAB9A (0.48) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL17350919 | 0.83 | LMNA (0.54) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL10243843 | 0.83 | LMNA (0.54) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL17350779 | 0.83 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL10243800 | 0.83 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL10243946 | 0.83 | ALDH1A1 (0.47) | PKLRALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL10243986 | 0.82 | ALDH1A1 (0.54) | ALDH1A1LMNATSHRSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |