Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922931 | 0.86 | POLB (0.53) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL1002836 | 0.80 | ALDH1A1 (0.43) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL4639194 | 0.76 | POLB (0.59) | POLBL3MBTL1KMT2ATSHRLMNA | |
| SCHEMBL366927 | 0.72 | CYP3A4 (0.44) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL17350918 | 0.72 | L3MBTL1 (0.38) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL31145307 | 0.72 | L3MBTL1 (0.38) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL17351119 | 0.71 | SPR (0.40) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL4639714 | 0.71 | POLB (0.53) | POLBL3MBTL1KMT2ATSHRLMNA | |
| SCHEMBL4046581 | 0.71 | GRM2 (0.40) | POLBL3MBTL1SPRKMT2ATSHR | |
| SCHEMBL17351004 | 0.70 | KDM4E (0.42) | POLBL3MBTL1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804865-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-12-23 | — | — | EP | claimed |