SCHEMBL366927

SCHEMBL366927

NC(=O)c1c(N)cc(Cl)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.44
SRC P12931 1/20 0.40
KDR P35968 1/20 0.40
ALDH1A1 P00352 3/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.39
GLA P06280 1/20 0.39
TSHR P16473 3/20 0.38
TP53 P04637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
POLB P06746 1/20 0.37
HSD17B10 Q99714 2/20 0.37
RECQL P46063 1/20 0.37
SPR P35270 1/20 0.37
PARP1 P09874 1/20 0.36
AKR1C4 P17516 1/20 0.36
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
AKR1C1 Q04828 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1002836 0.86 ALDH1A1 (0.43) CYP3A4SRCKDRALDH1A1GAA
SCHEMBL348918 0.83 CYP3A4 (0.53) CYP3A4SRCKDRALDH1A1GAA
SCHEMBL1398127 0.79 CYP3A4 (0.41) CYP3A4SRCKDRALDH1A1GAA
SCHEMBL1398108 0.79 GRM2 (0.37) CYP3A4GAAKDM4EPOLBSPR
SCHEMBL8048802 0.79 NMT1 (0.35) KDRGAAKDM4EGLATSHR
SCHEMBL4046581 0.77 GRM2 (0.40) CYP3A4SRCKDRALDH1A1GAA
SCHEMBL17351119 0.77 SPR (0.40) CYP3A4SRCKDRALDH1A1TSHR
SCHEMBL3922931 0.77 POLB (0.53) CYP3A4ALDH1A1GAATSHRL3MBTL1
SCHEMBL4214376 0.76 SCN10A (0.44) CYP3A4ALDH1A1KDM4EKMT2AHPGD
SCHEMBL3856555 0.76 ABL1 (0.54) CYP3A4ALDH1A1GAAKDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 EP disclosed
US-11407719-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2022-08-09 US disclosed
US-20210361656-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES HEPALINK (HONG KONG) LIMITED (HK) 2021-11-25 US disclosed
US-20210070716-A1 ANTI-INFLAMMATORY AGENTS HEPALINK (HONG KONG) LIMITED (HK) 2021-03-11 US disclosed
US-10882828-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2021-01-05 US disclosed
US-20200352946-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. 2020-11-12 US disclosed
CN-107964013-B Antifungal agent 詹森药业有限公司 2020-11-06 CN disclosed
US-20190119222-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2019-04-25 US disclosed
US-10131640-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2018-11-20 US disclosed
CN-107964013-A Antifungal agent 詹森药业有限公司 2018-04-27 CN disclosed
CN-103228659-A Benzene derivative substituted 5, 6-dihydro-4H-pyrrolo [1,2-A ] [1,4] benzodiazepine and 6H-pyrrolo [1,2-A ] [1,4] benzodiazepine antifungal agent JANSSEN PHARMACEUTICA NV 2013-07-31 CN disclosed
WO-2012069380-A1 ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-A][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2012-05-31 WO disclosed
US-20120040954-A1 NOVEL ANTI-INFLAMMATORY AGENTS HEPALINK (HONG KONG) LIMITED (HK) 2012-02-16 US disclosed
EP-2408454-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2012-01-25 EP disclosed
US-20120015905-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. 2012-01-19 US disclosed
US-8053440-B2 Compounds for the prevention and treatment of cardiovascular diseases Resverlogix Corporation (CA) 2011-11-08 US disclosed
WO-2010106436-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-09-23 WO disclosed
US-20080188467-A1 To regulate the expression of apolipoprotein A-I; atherosclerosis; improved pharmacological properties; 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one; to reduce cholesterol levels; agonists HEPALINK (HONG KONG) LIMITED (HK) 2008-08-07 US disclosed
US-4400507-A FOR COLORING POLYMERS, LACQUERS CIBA-GEIGY CORPORATION (US) 1983-08-23 US disclosed
US-4262120-A YELLOW TO ORANGE SHADES OF GOOD FASTNESS CIBA-GEIGY CORPORATION (US) 1981-04-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11407719-B2 Anti-inflammatory agents VCAM1, ICAM1, IL6 CYP3A4 3575/4885SRC 2560/4885KDR 592/4885
US-10882828-B2 Anti-inflammatory agents VCAM1, ICAM1, IL6 CYP3A4 3575/4885SRC 2560/4885KDR 592/4885
US-20210070716-A1 ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 CYP3A4 3575/4885SRC 2560/4885KDR 592/4885
US-20210361656-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES APOB, HDLBP, FABP3 CYP3A4 2473/4885SRC 3384/4885KDR 1649/4885
US-20120015905-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES APOB, HDLBP, FABP3 CYP3A4 2473/4885SRC 3384/4885KDR 1649/4885
US-10131640-B2 Anti-inflammatory agents VCAM1, ICAM1, IL6 CYP3A4 3575/4885SRC 2560/4885KDR 592/4885
US-20200352946-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES APOB, HDLBP, FABP3 CYP3A4 2473/4885SRC 3384/4885KDR 1649/4885
US-20080188467-A1 To regulate the expression of apolipoprotein A-I; atherosclerosis; improved pharmacological properties; 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one; to reduce cholesterol levels; agonists APOB, LDLR, APOL1 CYP3A4 1991/4885SRC 3625/4885KDR 924/4885
US-20190119222-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 CYP3A4 3427/4885SRC 2864/4885KDR 484/4885
US-20120040954-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 CYP3A4 3427/4885SRC 2864/4885KDR 484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.