SCHEMBL17352138

SCHEMBL17352138

COC(=O)Oc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CDK8 P49336 2/20 0.43
AR P10275 1/20 0.43
HTR2A P28223 1/20 0.42
SLC6A4 P31645 1/20 0.42
KCNH2 Q12809 1/20 0.42
NOTUM Q6P988 1/20 0.42
EPHX2 P34913 2/20 0.41
ACACB O00763 1/20 0.41
TAS1R3 Q7RTX0 2/20 0.41
TAS1R1 Q7RTX1 2/20 0.41
TAS1R2 Q8TE23 2/20 0.41
PTPN7 P35236 1/20 0.41
DUSP3 P51452 1/20 0.41
HDAC8 Q9BY41 1/20 0.40
PLA2G7 Q13093 1/20 0.40
KCNN4 O15554 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17352175 0.90 CDK8 (0.44) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17356410 0.87 KIF11 (0.45) NOTUMEPHX2
SCHEMBL17356478 0.86 ACACB (0.39) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17352140 0.86 CDK8 (0.43) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17356459 0.84 ELANE (0.51) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17355760 0.84 POLB (0.40) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL1893249 0.83 LMNA (0.44) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17356427 0.83 KCNN4 (0.46) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17352128 0.83 CDK8 (0.44) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL18697357 0.83 CDK8 (0.44) CDK8ARHTR2ASLC6A4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150372349-A1 NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE UBE INDUSTRIES, LTD. (JP) 2015-12-24 US claimed
US-10374256-B2 Nonaqueous electrolyte solution, electricity storage device using same, and phosphonoformic acid compound used in same UBE INDUSTRIES, LTD. (JP) 2019-08-06 US disclosed
EP-3086397-B1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND PHOSPHONOFORMIC ACID COMPOUND USED IN SAME UBE INDUSTRIES (JP) 2018-10-10 EP disclosed
EP-3012896-B1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND BIPHENYL GROUP-CONTAINING CARBONATE COMPOUND USED IN SAME UBE INDUSTRIES (JP) 2018-03-28 EP disclosed
US-20160315351-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND PHOSPHONOFORMIC ACID COMPOUND USED IN SAME UBE INDUSTRIES, LTD (JP) 2016-10-27 US disclosed
EP-3086397-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND PHOSPHONOFORMIC ACID COMPOUND USED IN SAME Ube Industries, Ltd. (JP) 2016-10-26 EP disclosed
US-20160126593-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND BIPHENYL GROUP-CONTAINING CARBONATE COMPOUND USED IN SAME UBE INDUSTRIES, LTD. (JP) 2016-05-05 US disclosed
EP-3012896-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND BIPHENYL GROUP-CONTAINING CARBONATE COMPOUND USED IN SAME UBE Industries, Ltd. (JP) 2016-04-27 EP disclosed
US-20150372349-A1 NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE UBE INDUSTRIES, LTD. (JP) 2015-12-24 US disclosed
US-20150372349-A1 NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE UBE INDUSTRIES, LTD. (JP) 2015-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160126593-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND BIPHENYL GROUP-CONTAINING CARBONATE COMPOUND USED IN SAME BMI1, KCNN2, CACNA2D4 CDK8 1447/4885AR 586/4885HTR2A 4169/4885
US-20150372349-A1 NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE HCN2, SCO2, HCN1 CDK8 4065/4885AR 3255/4885HTR2A 4567/4885
US-10374256-B2 Nonaqueous electrolyte solution, electricity storage device using same, and phosphonoformic acid compound used in same HCN2, PHOSPHO1, HCN1 CDK8 1564/4885AR 2736/4885HTR2A 4256/4885
US-20160315351-A1 NONAQUEOUS ELECTROLYTE SOLUTION, ELECTRICITY STORAGE DEVICE USING SAME, AND PHOSPHONOFORMIC ACID COMPOUND USED IN SAME HCN2, PHOSPHO1, HCN1 CDK8 1564/4885AR 2736/4885HTR2A 4256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.