Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956912 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KDM4ESMN1; SMN2PCSK9HPGD | |
| SCHEMBL8187571 | 0.76 | KDM4E (0.62) | ALDH1A1KDM4ESMN1; SMN2PCSK9HPGD | |
| SCHEMBL19002867 | 0.74 | ALDH1A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2PCSK9HPGD | |
| SCHEMBL5845328 | 0.74 | CYP2D6 (0.65) | ALDH1A1KDM4ESMN1; SMN2PCSK9HPGD | |
| SCHEMBL6800071 | 0.74 | CYP2D6 (0.65) | ALDH1A1KDM4ESMN1; SMN2PCSK9HPGD | |
| SCHEMBL15382054 | 0.74 | SMN1; SMN2 (0.59) | ALDH1A1KDM4ESMN1; SMN2PCSK9RAB9A | |
| SCHEMBL15382066 | 0.74 | SMN1; SMN2 (0.59) | ALDH1A1KDM4ESMN1; SMN2PCSK9RAB9A | |
| SCHEMBL2343301 | 0.74 | — | — | |
| SCHEMBL14067217 | 0.74 | — | — | |
| SCHEMBL12690881 | 0.74 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2PCSK9MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-9732093-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-15 | — | — | US | disclosed |
| US-20150368270-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALDH1A1 146/4885KDM4E 1986/4885SMN1; SMN2 3013/4885 |
| US-20150368270-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALDH1A1 146/4885KDM4E 1986/4885SMN1; SMN2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.