Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 14/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2243367 | 0.82 | SIRT1 (0.61) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL14615274 | 0.79 | MAPT (0.80) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL14615293 | 0.78 | MAPT (0.72) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL13679553 | 0.78 | MAPT (0.71) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL28373647 | 0.77 | NPC1 (0.69) | MAPTSMN1; SMN2TP53KDM4EKMT2A | |
| SCHEMBL14615276 | 0.77 | MAPT (0.76) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL13679550 | 0.77 | MAPT (0.70) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL4400767 | 0.77 | MAPT (0.63) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL27202488 | 0.76 | DDX3X (0.73) | THRBMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6260590 | 0.76 | KMT2A (0.53) | MAPTALDH1A1SMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216180-B2 | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay | NEW YORK UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216180-B2 | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay | NEW YORK UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |