Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719879 | 0.86 | KDM4E (0.58) | KDM4EPOLBTHRBMAPK1RAB9A | |
| SCHEMBL30408039 | 0.86 | KDM4E (0.58) | KDM4EPOLBTHRBMAPK1RAB9A | |
| SCHEMBL17354622 | 0.83 | AR (0.48) | — | |
| SCHEMBL17354628 | 0.83 | RXRA (0.40) | KDM4EMAPK1RAB9AGAAMEN1 | |
| SCHEMBL17354612 | 0.82 | KDM4E (0.44) | KDM4EPOLBRAB9ANPC1GAA | |
| SCHEMBL13721447 | 0.81 | MAPT (0.58) | KDM4EMAPK1RAB9ANPC1GAA | |
| SCHEMBL21581601 | 0.81 | DRD1 (0.40) | RAB9ANPC1KMT2AHAO1SCN10A | |
| SCHEMBL9918761 | 0.81 | AR (0.45) | POLBMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL16650619 | 0.80 | HRH3 (0.48) | KDM4EMAPK1RAB9ANPC1GAA | |
| SCHEMBL23952709 | 0.78 | KDM4E (0.46) | KDM4EPOLBTHRBMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216967-B2 | Imidazolidinedione derivatives | AUTIFONY THERAPEUTICS LIMITED (GB) | 2015-12-22 | — | — | US | disclosed |