Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 3/20 | 0.44 |
| ▸ | TK1 | P04183 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354760 | 0.77 | PI4KA (0.50) | — | |
| SCHEMBL27541246 | 0.73 | XDH (0.58) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL2983847 | 0.72 | XDH (0.57) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL1286945 | 0.72 | XDH (1.00) | XDHMEN1KMT2APNPTK1 | |
| Water SCHEMBL9697806 | 0.71 | XDH (0.56) | XDHMEN1KMT2APNPTK1 | |
| Hydrochloric Acid SCHEMBL21799342 | 0.71 | XDH (0.97) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL27923065 | 0.70 | XDH (0.55) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL986800 | 0.69 | XDH (0.60) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL4446276 | 0.69 | XDH (0.54) | XDHMEN1KMT2APNPTK1 | |
| SCHEMBL455494 | 0.69 | PNP (0.64) | MEN1KMT2APNPTK1HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370362-B2 | Pyrazine derivatives with extended conjugation and methods of using the same in optical applications | MEDIBEACON INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20160090376-A1 | PYRAZINE DERIVATIVES WITH EXTENDED CONJUGATION AND METHODS OF USING THE SAME IN OPTICAL APPLICATIONS | MALLINCKRODT INC. | 2016-03-31 | — | — | US | disclosed |
| US-9216963-B2 | Pyrazine derivatives with extended conjugation and methods of using the same in optical applications | MEDIBEACON INC. (US) | 2015-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370362-B2 | Pyrazine derivatives with extended conjugation and methods of using the same in optical applications | CYP3A5, PAICS, CYP3A43 | XDH 416/4885MEN1 1265/4885KMT2A 3849/4885 |
| US-20160090376-A1 | PYRAZINE DERIVATIVES WITH EXTENDED CONJUGATION AND METHODS OF USING THE SAME IN OPTICAL APPLICATIONS | CYP3A5, PAICS, CYP3A43 | XDH 416/4885MEN1 1265/4885KMT2A 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.