SCHEMBL17355183

SCHEMBL17355183

C=C1c2cc(OCc3ccccc3)ccc2CC12CCC(=O)CC2

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 12/20 0.53
MAOA P21397 10/20 0.53
TOP1 P11387 1/20 0.46
KDM1A O60341 2/20 0.44
HRH3 Q9Y5N1 1/20 0.43
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
NFKB1 P19838 1/20 0.43
GRM5 P41594 1/20 0.43
RAB9A P51151 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CREBBP Q92793 1/20 0.42
CA2 P00918 1/20 0.42
CA5A P35218 1/20 0.42
GSTP1 P09211 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12747715 0.88 MAOB (0.55) MAOBMAOATOP1KDM1AHRH3
SCHEMBL8778973 0.82 MAOA (0.56) MAOBMAOATOP1KDM1AHRH3
SCHEMBL12747654 0.77 MAOA (0.46) MAOBMAOANPC1HPGDRAB9A
SCHEMBL8778979 0.75 MAOA (0.56) MAOBMAOAKDM1AHRH3
SCHEMBL8778993 0.75 MAOB (0.63) MAOBMAOATOP1KDM1AHRH3
SCHEMBL12747660 0.74 MAOB (0.51) MAOBMAOATOP1KDM1AHRH3
SCHEMBL11703613 0.74 ALDH1A1 (0.41) MAOBMAOAALDH1A1HPGDSMN1; SMN2
SCHEMBL11769184 0.73 MAPT (0.39) MAOBMAOANPC1RAB9ACA2
SCHEMBL12747667 0.73 BACE1 (0.50) MAOBMAOATOP1KDM1AHRH3
SCHEMBL3408642 0.73 MAOB (0.58) MAOBMAOATOP1HRH3CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2406240-B1 INHIBITORS OF BETA-SECRETASE VITAE PHARMACEUTICALS INC (US) 2015-12-23 EP disclosed