SCHEMBL8778993

SCHEMBL8778993

O=C1c2cc(OCc3ccccc3)ccc2CCC12CCCC2

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 12/20 0.63
MAOA P21397 11/20 0.63
KDM1A O60341 2/20 0.49
TOP1 P11387 1/20 0.49
CA2 P00918 1/20 0.47
CA5A P35218 1/20 0.47
DRD2 P14416 2/20 0.46
HTR2A P28223 2/20 0.46
HTR2C P28335 2/20 0.46
HTR2B P41595 2/20 0.46
SIGMAR1 Q99720 2/20 0.46
HRH3 Q9Y5N1 1/20 0.46
NPC1 O15118 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HPGD P15428 1/20 0.45
NFKB1 P19838 1/20 0.45
GRM5 P41594 1/20 0.45
RAB9A P51151 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8779017 0.90 MAOB (0.63) MAOBMAOAKDM1ATOP1NPC1
SCHEMBL30769168 0.89 MAOB (0.65) MAOBMAOAKDM1ANPC1ALDH1A1
SCHEMBL8778973 0.85 MAOA (0.56) MAOBMAOAKDM1ATOP1CA2
SCHEMBL12747715 0.84 MAOB (0.55) MAOBMAOAKDM1ATOP1CA2
SCHEMBL30067289 0.78 MAOB (1.00) MAOBMAOANPC1ALDH1A1HPGD
SCHEMBL3501723 0.78 MAOB (1.00) MAOBMAOANPC1ALDH1A1HPGD
SCHEMBL7215662 0.78 MAOB (0.94) MAOBMAOANPC1ALDH1A1HPGD
SCHEMBL8778979 0.78 MAOA (0.56) MAOBMAOAKDM1AHRH3
SCHEMBL12747660 0.77 MAOB (0.51) MAOBMAOAKDM1ATOP1HRH3
SCHEMBL8779124 0.77 HTR2A (0.51) MAOBMAOACA2DRD2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0606661-B1 Octahydrophenanthrene derivatives and their use as NMDA-Antagonists HOFFMANN LA ROCHE (CH) 1997-03-12 EP disclosed
US-5385947-A For prevention of nerve damage due to reduction of blood or oxygen supplies HOFFMANN-LA ROCHE INC. (US) 1995-01-31 US disclosed
EP-0606661-A1 Octahydrophenanthrene derivatives and their use as NMDA-Antagonists F. HOFFMANN-LA ROCHE AG (CH) 1994-07-20 EP disclosed