Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071317 | 0.91 | KDM5A (0.36) | ALDH1A1KDM4EHSD17B10SIGMAR1CCNT1 | |
| SCHEMBL18692782 | 0.81 | HPGD (0.43) | ALDH1A1KDM4EHSD17B10HPGDKCNH2 | |
| SCHEMBL3364096 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL31462462 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL18692292 | 0.79 | HPGD (0.41) | ALDH1A1KDM4EHSD17B10HPGDKCNH2 | |
| SCHEMBL16347011 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10HPGDKCNH2 | |
| SCHEMBL23748795 | 0.77 | KDM4E (0.46) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL10282157 | 0.76 | HPGD (0.45) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL19300056 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL21191295 | 0.76 | CYP4F2 (0.43) | ALDH1A1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695198-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150368269-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368269-A1 | Factor IXa Inhibitors | F9, TFPI, F13B | ALDH1A1 1321/4885KDM4E 1014/4885HSD17B10 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.