Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 6/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364096 | 0.98 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 | |
| SCHEMBL31462462 | 0.98 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 | |
| SCHEMBL15935405 | 0.91 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 | |
| SCHEMBL28720539 | 0.84 | SMN1; SMN2 (0.38) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 | |
| SCHEMBL13135665 | 0.82 | ALOX15 (0.51) | SIGMAR1SMN1; SMN2KDM5ADRD2DRD4 | |
| SCHEMBL15832226 | 0.82 | SIGMAR1 (0.43) | KDM4EALDH1A1SIGMAR1SMN1; SMN2KCNJ6 | |
| SCHEMBL2852441 | 0.82 | MEN1 (0.46) | ALDH1A1SMN1; SMN2KDM5A | |
| SCHEMBL21024021 | 0.82 | SMN1; SMN2 (0.38) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 | |
| SCHEMBL18865625 | 0.81 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2KDM5ADRD2DRD4 | |
| SCHEMBL17053344 | 0.81 | SIGMAR1 (0.40) | KDM4EALDH1A1HSD17B10SIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3863711-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | Pliant Therapeutics, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |