Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15923709 | 0.90 | SIGMAR1 (0.34) | ALDH1A1KDM4EHSD17B10SIGMAR1GAA | |
| SCHEMBL23546398 | 0.82 | MEN1 (0.44) | ALDH1A1MAPTTDP1 | |
| SCHEMBL3364096 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL31437760 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10HPGDESR1 | |
| SCHEMBL31462462 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL19300122 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10HPGDESR1 | |
| SCHEMBL23748795 | 0.79 | KDM4E (0.46) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL10282157 | 0.78 | HPGD (0.45) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL21191294 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD | |
| SCHEMBL17356152 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10SIGMAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |