Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18671037 | 0.89 | ADORA1 (0.37) | — | |
| SCHEMBL17358551 | 0.84 | ADORA2A (0.36) | — | |
| SCHEMBL17358549 | 0.82 | ADORA1 (0.35) | — | |
| SCHEMBL19859339 | 0.79 | PRMT5 (0.35) | PRMT5WDR77TP53ADK | |
| SCHEMBL17358548 | 0.78 | ADORA2B (0.37) | — | |
| SCHEMBL19859685 | 0.75 | PRMT5 (0.35) | PRMT5WDR77TP53ADKNPC1 | |
| SCHEMBL16368173 | 0.75 | ADORA1 (0.36) | — | |
| SCHEMBL16640008 | 0.75 | ADORA1 (0.36) | — | |
| SCHEMBL16368169 | 0.75 | ADORA1 (0.36) | — | |
| SCHEMBL5927479 | 0.74 | ADORA3 (0.51) | PRMT5WDR77ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NUDT1, NT5C3B | PRMT5 2111/4885WDR77 1587/4885TP53 2544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.