Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17366247 | 0.85 | GPR119 (0.61) | LMNARAB9ASMN1; SMN2CCR1NPC1 | |
| SCHEMBL28174922 | 0.83 | TDP1 (0.50) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL3033970 | 0.83 | FDFT1 (0.55) | TDP1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15984671 | 0.82 | KMT2A (0.58) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL27037680 | 0.82 | MRGPRX4 (0.57) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL28044746 | 0.81 | LMNA (0.48) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL6418433 | 0.81 | DRD4 (0.56) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL23783282 | 0.80 | KMT2A (0.49) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL6419976 | 0.80 | HDAC3 (0.54) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL4035554 | 0.80 | SMN1; SMN2 (0.72) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960238-B1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2960238-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |