Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 1/20 | 0.39 |
| ▸ | ATP4B | P51164 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17360345 | 0.88 | SRD5A2 (0.46) | ELANECTSGSRD5A1SRD5A2BRD4 | |
| SCHEMBL15984664 | 0.85 | ELANE (0.42) | ELANEF2CTSGSRD5A1SRD5A2 | |
| SCHEMBL28174958 | 0.78 | ELANE (0.41) | ELANEF2CTSGSRD5A1SRD5A2 | |
| SCHEMBL29264495 | 0.77 | SRD5A1 (0.49) | SRD5A1SRD5A2PTGER1BRD4MRGPRX4 | |
| SCHEMBL21274686 | 0.76 | ALOX5 (0.54) | SRD5A2MRGPRX4NPC1RAB9A | |
| SCHEMBL5483649 | 0.76 | SRD5A2 (0.57) | SRD5A2MRGPRX4NPC1RAB9A | |
| SCHEMBL7330439 | 0.76 | ELANE (0.52) | ELANEF2CTSGMRGPRX4NPC1 | |
| SCHEMBL17360612 | 0.75 | SRD5A1 (0.41) | SRD5A1SRD5A2PTGER1BRD4NPC1 | |
| SCHEMBL28659489 | 0.72 | ROCK1 (0.50) | SRD5A2PTGER1BRD4MRGPRX4SGMS2 | |
| SCHEMBL18474166 | 0.70 | SRD5A1 (0.55) | SRD5A1SRD5A2MRGPRX4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073730-B | monocyclic pyridine derivatives | 卫材R&D管理有限公司 | 2017-10-13 | — | — | CN | disclosed |
| EP-2960238-B1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2960238-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |