Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17360243 | 0.88 | ELANE (0.47) | SRD5A2SRD5A1BRD4FFAR4SMN1; SMN2 | |
| SCHEMBL17360612 | 0.87 | SRD5A1 (0.41) | SRD5A2SRD5A1BRD4SMN1; SMN2HPGD | |
| SCHEMBL15984664 | 0.77 | ELANE (0.42) | SRD5A2SRD5A1BRD4ELANECTSG | |
| SCHEMBL29264495 | 0.75 | SRD5A1 (0.49) | SRD5A2SRD5A1BRD4SMN1; SMN2NPC1 | |
| SCHEMBL21274686 | 0.75 | ALOX5 (0.54) | SRD5A2HPGDNPC1RAB9AHDAC1 | |
| SCHEMBL5483649 | 0.75 | SRD5A2 (0.57) | SRD5A2HPGDNPC1RAB9AHDAC1 | |
| SCHEMBL18474166 | 0.73 | SRD5A1 (0.55) | SRD5A2SRD5A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL3916932 | 0.73 | TUBB1 (0.58) | SRD5A2SRD5A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL7163724 | 0.72 | SRD5A1 (0.51) | SRD5A2SRD5A1BRD4SMN1; SMN2HPGD | |
| SCHEMBL3912610 | 0.70 | TRPV3 (0.41) | SRD5A2SRD5A1BRD4NPC1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960238-B1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2960238-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |