Gallamine

Gallamine

SCHEMBL1736255

CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC.I[IH]I

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Gallamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.87
ALOX15 P16050 2/20 0.87
LMNA P02545 1/20 0.87
CHRM1 P11229 1/20 0.87
TSHR P16473 1/20 0.87
ACHE P22303 1/20 0.87
KCNH2 Q12809 1/20 0.87
HIF1A Q16665 1/20 0.87
CHRNA7 P36544 16/20 0.50
CHRNB4 P30926 11/20 0.50
CHRNA3 P32297 11/20 0.50
CHRNB2 P17787 9/20 0.50
CHRNA4 P43681 9/20 0.50
MAPT P10636 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gallamine SCHEMBL12638600 0.93 CHRM2 (1.00) CHRM2ALOX15LMNACHRM1TSHR
Gallamine SCHEMBL249090 0.91 CHRM2 (1.00) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL19300483 0.88 CHRM2 (0.90) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL16884476 0.81 CHRM2 (0.77) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL8557526 0.72 LMNA (0.62) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL3265285 0.71 CHRM2 (0.59) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL1238407 0.70 LMNA (0.60) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL13658189 0.68 LMNA (0.58) CHRM2ALOX15LMNACHRM1TSHR
SCHEMBL13385235 0.67 CHRNA7 (1.00) ALOX15CHRNA7CHRNB4CHRNA3CHRNB2
SCHEMBL453505 0.67 CHRM2 (0.56) CHRM2ALOX15LMNACHRM1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3042718-A1 DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION Dietz, Ulrich (DE) 2016-07-13 EP disclosed
US-20160122686-A1 DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION DIETZ ULRICH (DE) 2016-05-05 US disclosed
EP-2585420-B1 METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION DIETZ ULRICH (DE) 2016-04-06 EP disclosed
US-9127233-B2 Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by means of micro-or nanoemulsification Dietz, Ulrich (DE) 2015-09-08 US disclosed
EP-2585420-A2 DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION Dietz, Ulrich (DE) 2013-05-01 EP disclosed
US-20130090488-A1 DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION DIETZ ULRICH (DE) 2013-04-11 US disclosed
WO-2011160857-A2 DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION DIETZ ULRICH (DE) 2011-12-29 WO disclosed
EP-2399885-A1 Device and method for solubilizing, separating, removing and reacting carboxylic acids in aqueous or organic solutions by means of micro- or nanoemulsification Dietz, Ulrich (DE) 2011-12-28 EP disclosed