Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | HTR1E | P28566 | 4/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722715 | 0.88 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL6722720 | 0.88 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL6820592 | 0.81 | TAS2R14 (0.52) | ALDH1A1MAPTHTR1ES1PR3LMNA | |
| SCHEMBL30452459 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTHTR1ES1PR3LMNA | |
| SCHEMBL6723553 | 0.80 | ROCK2 (0.58) | ALDH1A1S1PR3GAAMEN1KMT2A | |
| SCHEMBL6717100 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPTHTR1ES1PR3LMNA | |
| SCHEMBL3836963 | 0.80 | ROCK2 (0.58) | ALDH1A1S1PR3GAAMEN1KMT2A | |
| SCHEMBL6717109 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPTHTR1ES1PR3LMNA | |
| SCHEMBL23611208 | 0.80 | ROCK2 (0.56) | ALDH1A1MAPTHTR1ES1PR3HTT | |
| SCHEMBL23611205 | 0.80 | ROCK2 (0.56) | ALDH1A1MAPTHTR1ES1PR3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10131637-B2 | Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases | SHIFA BIOMEDICAL CORPORATION (US) | 2018-11-20 | — | — | US | disclosed |
| US-20180079730-A1 | ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | SHIFA BIOMEDICAL CORP (US) | 2018-03-22 | — | — | US | disclosed |
| US-20150376139-A1 | ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079730-A1 | ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | PCSK9, PCSK7, PCSK6 | ALDH1A1 4302/4885MAPT 2814/4885HTR1E 3575/4885 |
| US-10131637-B2 | Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases | PCSK9, PCSK7, PCSK6 | ALDH1A1 3044/4885MAPT 2320/4885HTR1E 3201/4885 |
| US-20150376139-A1 | ANTI-PCSK9 COMPOUNDS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | PCSK9, PCSK7, PCSK6 | ALDH1A1 4302/4885MAPT 2814/4885HTR1E 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.