Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 9/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364293 | 0.80 | KDM4E (0.44) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| SCHEMBL1272494 | 0.78 | LMNA (0.47) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| SCHEMBL17367387 | 0.77 | CA12 (0.33) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| Hydrochloric Acid SCHEMBL17364313 | 0.75 | CA12 (0.35) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| Hydrochloric Acid SCHEMBL17364306 | 0.71 | HTT (0.44) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL29349831 | 0.69 | LRRK2 (1.00) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL152594 | 0.69 | LRRK2 (1.00) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL11157548 | 0.67 | PDPK1 (0.96) | PDPK1LRRK2CHEK1AURKACHEK2 | |
| SCHEMBL17367352 | 0.65 | XDH (0.30) | XDH | |
| SCHEMBL27615224 | 0.65 | PDPK1 (0.66) | PDPK1LRRK2CHEK1AURKACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150376219-A1 | Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods | ZHONG MINGHONG (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150376219-A1 | Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods | ZHONG MINGHONG (US) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376219-A1 | Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods | PNP, ATIC, NT5C3B | PDPK1 939/4885LRRK2 2211/4885CHEK1 1272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.