Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17366150 | 0.83 | MDM2 (0.55) | MDM2TP53CYP11B1CYP11B2CA12 | |
| SCHEMBL17366161 | 0.83 | MDM2 (0.51) | MDM2TP53CA12CA2CA9 | |
| SCHEMBL30121977 | 0.72 | MDM2 (0.64) | MDM2TP53CA12CA9 | |
| SCHEMBL17366176 | 0.70 | MDM2 (0.53) | MDM2TP53 | |
| SCHEMBL21829964 | 0.68 | P2RX3 (0.41) | MDM2TP53CYP11B1CYP11B2 | |
| SCHEMBL2463170 | 0.68 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL17366169 | 0.67 | MDM2 (0.58) | MDM2TP53CA12CA9 | |
| SCHEMBL17366151 | 0.67 | MDM2 (0.58) | MDM2TP53 | |
| SCHEMBL17366174 | 0.67 | MDM2 (0.58) | MDM2TP53 | |
| SCHEMBL17366167 | 0.67 | MDM2 (0.48) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-B1 | NEW THERAPEUTIC AGENTS | CANCER RESEARCH TECH LTD (GB) | 2019-10-30 | — | — | EP | disclosed |
| EP-2960233-A1 | NEW THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2015-12-30 | — | — | EP | disclosed |