Sugi Predict

Sugi Predict / Compounds / SCHEMBL17366377

SCHEMBL17366377

SCHEMBL17366377

C(=C/c1ccc(N(c2ccc(/C=C/C=N/N(c3ccccc3)c3ccccc3)cc2)c2ccccc2-c2ccccc2)cc1)\C=N\N(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ CYP2C19 P33261 2/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ ALDH1A1 P00352 5/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ USP2 O75604 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ MAPK1 P28482 2/20 0.33
▸ CTNNB1 P35222 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ HTT P42858 2/20 0.33
▸ RELA Q04206 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13239565 0.84 MAOB (0.47) CYP1A2CYP3A4CYP2C19ALDH1A1KMT2A
SCHEMBL18417169 0.83 MAOB (0.45) ALDH1A1KMT2AMEN1USP2MAPT
SCHEMBL15761073 0.83 MAOB (0.45) ALDH1A1KMT2AMEN1USP2MAPT
SCHEMBL17366360 0.83 MAOB (0.45) HPGDCYP1A2CYP3A4CYP2C19CYP2D6
SCHEMBL14196506 0.82 RELA (0.47) HPGDCYP1A2CYP3A4CYP2C19CYP2D6
SCHEMBL17549425 0.81 MAOB (0.44) ALDH1A1KMT2AMEN1USP2MAPT
SCHEMBL17366361 0.81 HTT (0.36) HPGDCYP1A2CYP3A4CYP2C19CYP2D6
SCHEMBL18416522 0.80 MAOB (0.42) ALDH1A1KMT2AMEN1USP2MAPT
SCHEMBL17366378 0.79 MAPT (0.40) CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9
SCHEMBL14196514 0.78 RELA (0.46) ALDH1A1KMT2AMEN1USP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2960229-B1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC (JP) 2017-02-15 — — EP disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 — — US disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 — — US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 — — US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 — — US disclosed
EP-2960229-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER Kyocera Document Solutions Inc. (JP) 2015-12-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER NAT1, GSTA1, PKN1 HPGD 614/4885CYP1A2 250/4885CYP3A4 270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.