Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | CD44 | P16070 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174815 | 0.90 | HTR2A (0.40) | HTR2AHTR2CMEN1KMT2ADRD2 | |
| SCHEMBL173574 | 0.88 | HTR2A (0.39) | HTR2AHTR2CMEN1KMT2ADRD2 | |
| SCHEMBL174565 | 0.84 | KIF11 (0.34) | HTR2AHTR2CMEN1KMT2ADRD2 | |
| SCHEMBL174466 | 0.84 | HTR2A (0.54) | HTR2AHTR2CSLC6A2SLC6A4HTR2B | |
| SCHEMBL174416 | 0.82 | HTR2A (0.40) | HTR2AHTR2CMEN1KMT2ADRD2 | |
| SCHEMBL175131 | 0.82 | HTR2A (0.40) | HTR2AHTR2CMEN1KMT2ADRD2 | |
| SCHEMBL175226 | 0.79 | SLC13A5 (0.36) | HTR2AMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL173622 | 0.79 | HTR2A (0.57) | HTR2AHTR2CSLC6A2SLC6A4HTR2B | |
| Adipic Acid SCHEMBL173981 | 0.75 | L3MBTL1 (0.41) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL174886 | 0.75 | HTR2A (0.41) | HTR2AHTR2CMEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |