Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173819 | 0.87 | HTR2A (0.46) | HTR2A | |
| Citric Acid SCHEMBL173747 | 0.83 | SLC13A5 (0.39) | SLC13A5KDM4ELMNACYP1A2CYP2D6 | |
| SCHEMBL174815 | 0.81 | HTR2A (0.40) | MEN1KMT2AHTR2A | |
| SCHEMBL173574 | 0.81 | HTR2A (0.39) | LMNATDP1MEN1KMT2AHTR2A | |
| SCHEMBL173679 | 0.79 | HTR2A (0.38) | LMNAALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL175131 | 0.74 | HTR2A (0.40) | LMNAALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL174416 | 0.74 | HTR2A (0.40) | LMNAALDH1A1MEN1KMT2AHTR2A | |
| Citric Acid SCHEMBL27499903 | 0.72 | PNMT (0.56) | SLC13A5KDM4ELMNACYP1A2CYP2D6 | |
| SCHEMBL174565 | 0.72 | KIF11 (0.34) | MEN1KMT2AHTR2A | |
| Glycolic Acid SCHEMBL174591 | 0.70 | HTR2A (0.41) | LMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |