Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL175159 | 0.95 | HTR2A (0.41) | L3MBTL1HTR2AHTR2CALDH1A1DRD2 | |
| Glycolic Acid SCHEMBL174591 | 0.89 | HTR2A (0.41) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Malonic Acid SCHEMBL174326 | 0.89 | HTR2A (0.41) | HTR2AHTR2CALDH1A1DRD2SLC6A2 | |
| Alpha-Ketoglutaric Acid SCHEMBL174485 | 0.89 | HTR2A (0.37) | L3MBTL1MAPK1HTR2AHTR2CALDH1A1 | |
| SCHEMBL173319 | 0.84 | HTR2A (0.51) | MAPK1HTR2AHTR2CDRD2SLC6A2 | |
| Hydrochloric Acid SCHEMBL5317898 | 0.83 | HTR2A (0.50) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Citric Acid SCHEMBL173747 | 0.83 | SLC13A5 (0.39) | L3MBTL1MAPK1HTR2AHTR2CALDH1A1 | |
| Phosphoric Acid SCHEMBL174685 | 0.82 | HTR2A (0.44) | L3MBTL1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL174465 | 0.81 | HTR2C (0.43) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL173679 | 0.75 | HTR2A (0.38) | L3MBTL1HTR2AHTR2CALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |