SCHEMBL1737566

SCHEMBL1737566

Cc1c(C)n(Cc2cccc(F)c2)c2c(N3CCc4cc(F)ccc4C3C)nccc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.35
DPP4 P27487 1/20 0.35
PLA2G2A P14555 1/20 0.35
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
HSD17B10 Q99714 1/20 0.34
PDE1A P54750 6/20 0.34
PDE1B Q01064 6/20 0.34
PDE1C Q14123 6/20 0.34
HTR2A P28223 3/20 0.34
MAPT P10636 1/20 0.34
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34
ENPP2 Q13822 3/20 0.34
HTR1A P08908 2/20 0.34
DRD2 P14416 2/20 0.34
HTR7 P34969 2/20 0.34
FABP4 P15090 1/20 0.34
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1737036 0.99 HTR6 (0.35) HTR6DPP4PLA2G2AMEN1ALDH1A1
SCHEMBL1736043 0.94 HTR6 (0.35) HTR6DPP4PLA2G2AMEN1ALDH1A1
SCHEMBL1738012 0.94 FABP4 (0.35) HTR6DPP4PLA2G2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL1736728 0.93 FABP4 (0.35) HTR6DPP4PLA2G2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL1736873 0.93 HTR6 (0.34) HTR6DPP4PLA2G2AMEN1ALDH1A1
SCHEMBL1737665 0.89 HTR6 (0.35) HTR6DPP4PLA2G2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL1737491 0.88 HTR6 (0.34) HTR6DPP4PLA2G2APDE1APDE1B
SCHEMBL1737168 0.88 CCNT1 (0.37) MEN1ALDH1A1KMT2AMAPTKDM4E
SCHEMBL1738899 0.88 CYP1A2 (0.33) MEN1KMT2ACYP1A2CYP3A4CYP2D6
SCHEMBL1737781 0.88 MAPT (0.39) PLA2G2AALDH1A1HSD17B10MAPTENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed