Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174473 | 0.88 | MEN1 (0.55) | SMN1; SMN2MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL167730 | 0.86 | MEN1 (0.57) | POLBMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL175118 | 0.83 | RAB9A (0.58) | SMN1; SMN2MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL174238 | 0.83 | DDX3X (0.52) | POLBMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL175262 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL27807412 | 0.82 | MAPT (0.51) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL4569778 | 0.81 | MEN1 (0.53) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL175199 | 0.80 | HTT (0.51) | MAPTRAB9ANPC1ALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL167491 | 0.80 | KMT2A (0.50) | POLBMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL15077842 | 0.79 | IGF1R (0.48) | POLBMAPTRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611806-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Ascepion Pharmaceuticals, Inc. (CN) | 2013-07-10 | — | — | EP | claimed |
| WO-2012028106-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2012-03-08 | — | — | WO | claimed |
| EP-2611806-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Ascepion Pharmaceuticals, Inc. (CN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028106-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2012-03-08 | — | — | WO | disclosed |