Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.56 |
| ▸ | FEN1 | P39748 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38141 | 0.88 | ERCC5 (0.58) | ERCC5FEN1ALDH1A1CES2CES1 | |
| SCHEMBL29621373 | 0.88 | ERCC5 (0.58) | ERCC5FEN1ALDH1A1CES2CES1 | |
| Bromide SCHEMBL235266 | 0.86 | ERCC5 (0.56) | ERCC5FEN1ALDH1A1CES2CES1 | |
| SCHEMBL1045114 | 0.77 | GSK3B (0.76) | ERCC5FEN1ALDH1A1CES1PTPN1 | |
| Carbon Monoxide SCHEMBL8747366 | 0.76 | ALDH1A1 (0.68) | ERCC5FEN1ALDH1A1CES2CES1 | |
| Bromoacetic Acid SCHEMBL7366623 | 0.76 | CYP3A4 (0.57) | CES2CES1PTPN1GSK3BCYP3A4 | |
| SCHEMBL7863427 | 0.75 | GSK3B (0.52) | ERCC5FEN1ALDH1A1CES2CES1 | |
| SCHEMBL1162402 | 0.74 | CYP3A4 (0.55) | ERCC5FEN1ALDH1A1CES2CES1 | |
| SCHEMBL9409754 | 0.73 | PTPN1 (0.65) | ALDH1A1CES1PTPN1GSK3BMAPT | |
| SCHEMBL17375912 | 0.73 | ERCC5 (0.56) | ERCC5FEN1PTPN1GSK3BCXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170198006-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-07-13 | — | — | US | disclosed |
| EP-3160477-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200680-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170198006-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | ERCC5 545/4885FEN1 1673/4885ALDH1A1 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.