Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 8/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377134 | 0.84 | NT5E (0.36) | HINT1NT5EADORA3 | |
| SCHEMBL23171224 | 0.83 | HINT1 (0.51) | HINT1GSK3ARPS6KA3MAPK14HPGD | |
| SCHEMBL15588881 | 0.80 | ADORA2A (0.53) | HINT1GSK3ARPS6KA3MAPK14HPGD | |
| SCHEMBL25713349 | 0.80 | HINT1 (0.54) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL16480819 | 0.80 | HINT1 (0.41) | HINT1GSK3ARPS6KA3MAPK14HPGD | |
| SCHEMBL20059042 | 0.78 | HINT1 (0.44) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL16689919 | 0.78 | HINT1 (0.48) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL16690082 | 0.78 | HINT1 (0.48) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL23348945 | 0.78 | HINT1 (0.48) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL20059085 | 0.78 | HINT1 (0.48) | HINT1GSK3ARPS6KA3MAPK14TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797782-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTIONS | Janssen BioPharma, Inc. (US) | 2021-03-31 | — | — | EP | disclosed |
| EP-3160476-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION | JANSSEN BIOPHARMA INC (US) | 2020-09-30 | — | — | EP | disclosed |
| WO-2015200205-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | ALIOS BIOPHARMA, INC. (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015200219-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | ALIOS BIOPHARMA, INC. (US) | 2015-12-30 | — | — | WO | disclosed |